In 2017, humans live in near-total isolation, rarely leaving the safety and comfort of their homes, thanks to remotely-controlled robotic bodies that serve as “surrogates,” designed as better-looking versions of their human operators. Because people are safe all the time, and damage done to a surrogate is not felt by its owner, it is a peaceful world free from fear, pain, and crime.

Agent Tom Greer (Bruce Willis) is an FBI agent who, through the use of his own surrogate, investigates the first murder in years: Jarod Canter, a college student and the son of Dr. Lionel Canter (James Cromwell), the original inventor of surrogates, who uses multiple surrogates himself. The case grows more complicated, however, when several police officers are murdered when their surrogates are destroyed, something which is not supposed to happen, as the human operator is normally safe from the damage done to his/her surrogate.

Greer’s investigation leads him to the Dreads, a group of humans led by a mysterious man known only as The Prophet (Ving Rhames) who is against the use of surrogates. Greer and his partner Jennifer Peters (Radha Mitchell) determine that the identity of the murderer is a Dread named Miles Strickland. Strickland used a unique weapon called an O.D. (Overload Device) to kill Jarod as well as five police officers tracking him. Greer himself barely escapes death by the weapon. Although his surrogate is physically damaged, it is able to pursue Strickland before it is destroyed by the Dreads.

Suffering damages from the weapon, Greer is found in his apartment by his wife Maggie (Rosamund Pike). She prefers interacting through her surrogate, even with her husband in the privacy of their home. We learn that the couple is particularly distant from each other as they grieve over their young son who died in a car accident. (We see that, from the brief scenes in the film including the real Maggie, she is severely depressed and simultaneously takes many medications.) Greer is taken to the hospital and survives, although he is suspended and will not be issued another surrogate while his actions are investigated.

At the Dread Reservation, Strickland is approached by The Prophet who demands information about the weapon. Strickland is apparently killed by The Prophet or his followers. When Greer goes into the Reservation, he stumbles upon Strickland’s funeral and then approaches The Prophet, asking about the weapon Strickland used. As Greer leaves the Reservation, it is revealed that The Prophet has the weapon. Greer meets with Dr. Canter, again using one of his surrogates, who suggests the weapon was manufactured by the military. Greer meets with a member of the military and learns that the weapon sends a computer virus into the surrogates that shuts them down, but it disables the fail-safe mechanisms and kills the operator.